Clinical research investigating Floatation-REST has reported largely beneficial effects across a range of different stress- and pain-related conditions, including hypertension, chronic tension headaches, chronic muscle tension pain in the back and neck, and stress-related pain with burnout depression. There have also been several studies focused on individuals with clinical anxiety, including generalized anxiety disorder, posttraumatic stress disorder (PTSD), anorexia nervosa, panic disorder, agoraphobia, and social anxiety disorder, with many of these patients also presenting with comorbid major depressive disorder. The evidence published thus far suggests that Floatation-REST is a safe technique for rapidly reducing levels of stress, pain, and anxiety. Clinical trials are currently underway in America, Germany, and Sweden investigating the long-term impact of floating in patients with anxiety disorders, anorexia nervosa, chronic pain, fibromyalgia, and insomnia. As the evidence base continues to grow, we will continue to update this repository of peer-reviewed publications studying the clinical effects of Floatation-REST.